Bioactive Small Molecules

A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.

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4,771 – 4,785 of 60,549 results

4,771

Apexbio Technology LLC Coumarin Thioester, 25mg. Cas: N/A MFCD: NA. N-terminal protein fluorescent labeling

N-terminal protein fluorescent labeling Other sizes are available. Please inqury us for quote.

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4,772

Echelon Biosciences Research Labs Caerulein - 1 mg, CAS#: 17650-98-5

Caerulein - 1mg , Glp-Gln-Asp-Tyr(SO3H)-Thr-Gly-Trp-Met-Asp-Phe-NH2 This item is non returnable

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4,773

Echelon Biosciences Research Labs Selective PAR-1 agonist - 5 mg, CAS#: 197794-83-5

Selective PAR-1 agonist - 5mg , Thr-Phe-Leu-Leu-Arg-NH2 This item is non returnable

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4,774

Selleck Chemical LLC Patritumab deruxtecan

Patritumab deruxtecan (HER3-DXd) is an antibody-drug conjugate (ADC) composed of a fully human anti-HER3 IgG1 monoclonal antibody and a cytotixic topoisomerase I inhibitor Patritumab deruxtecan shows anticancer activity

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4,775

Cayman Chemical PQ401, Purity: ≥98%, CAS: 196868-63-0, 10 mg

An inhibitor of IGF-1R; inhibits autophosphorylation of the recombinant IGF-1R kinase domain (IC50 = 50 = 12 μM); reduces cell viability of U87MG glioma cells (IC50 = 5 μM) and induces apoptosis and inhibits cell migration in a concentration-dependent manner; inhibits IGF-1-stimulated proliferation of MCF-7 cells in vitro (IC50 = 6 μM) and reduces tumor growth in an MCNeuA model of murine breast cancer at 50 and 100 mg/kg; has antimalarial activity against P. falciparum strain 3D7 (EC50 = 53 nM)

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4,776

Cayman Chemical Teicoplanin A2-3, Purity: ≥85%, CAS: 91032-36-9, 5 mg

A major component of the teicoplanin complex, a glycopeptide antibiotic produced by A. teichomyceticus that is broadly effective against Gram-positive bacteria

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4,777

STEMCELL Technologies 8-Bromo-cAMP, Size: 100 mg

8-Bromo-cAMP is a membrane-permeable cAMP derivative. It can activate cAMP-dependent protein kinase, with long-acting effects due to its resistance to cAMP phosphodiesterase (Schwede et al.). It can be used to study calcium-mediated pathways (IC₅₀ = 0.84 mM; Xaus et al.).REPROGRAMMING · Improves the reprogramming efficiency of human neonatal foreskin fibroblast (HFF1) cells, in combination with valproic acid (Wang & Adjaye). IMMUNOLOGY · Inhibits M-CSF-dependent proliferation of macrophages (Xaus et al.). · Protects neutrophils against TNF-α-induced apoptosis (Krakstad). CANCER RESEARCH · Induces a proliferative response in an IL-3-dependent leukemic cell line (Barge et al.).· Induces membrane depolarization in pancreatic cancer cell lines (Sorio et al.).

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4,778

Cayman Chemical ANTIBODY DAF-2 100UG

DAF-2 is a sensitive fluorescent indicator commonly used for the detection of NO.{6360,6632} It reacts with NO in the presence of oxygen to yield the highly fluorescent triazolofluorescein (DAF-2T). Fluorescence is monitored using excitation and emission wavelengths of 485 and 538 nM, respectively.{6632} At neutral pH the detection limit for NO is 2-5 nM.

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4,779

Cayman Chemical SGI-7079, Purity: ≥98%, CAS: 1239875-86-5, 5 mg

An Axl kinase inhibitor; inhibits proliferation of inflammatory breast cancer cells (IC50s = 0.43 and 0.15 µM for SUM149 and KPL-4 cells, respectively); synergistically increases the potency of erlotinib on EGFR inhibition; dose-dependently inhibits tumor growth in a mouse xenograft model of non-small cell lung cancer

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4,780

Apexbio Technology LLC LY3009120 1454682-72-4 25mg

LY3009120 (CAS 1454682-72-4) is a pan-RAF inhibitor that targets both monomeric and dimeric forms of RAF kinases including wild-type BRAF CRAF and mutant forms such as BRAFV600E and BRAFV600E G468A with IC50 values ranging from 5 8 to 17 nM By suppressing RAF activity LY3009120 disrupts downstream phosphorylation of MEK and ERK modulating MAPK/ERK signaling involved in cell proliferation and survival In cell models harboring NRAS or KRAS mutations as well as BRAF V600E mutant melanoma LY3009120 induces G0/G1 cell cycle arrest and minimizes paradoxical pathway activation In vivo it achieves dose-dependent inhibition of MEK and ERK phosphorylation and drives near-complete tumor regression in xenograft models LY3009120 is valuable for investigating RAF-mediated oncogenic processes and resistance mechanisms in MAPK-driven cancers

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4,781

Medchemexpress LLC (rel)-PROTAC ERRα Degrader-1 | 98.2% | 1 MG

(rel)-PROTAC ERRα Degrader-1 is a relative configuration of PROTAC ERRα Degrader-1, comprising an MDM2 ligand binding group, a linker, and an estrogen-related receptor alpha (ERRα) binding group. It functions as an estrogen-related receptor alpha (ERRα) degrader.

Molecular weight: 1108.92
Molecular formula: C₅₄H₄₉Cl₂F₆N₇O₈
Appearance: Off-white to light yellow solid
Purity: 98.18%
Soluble in DMSO at 100 mg/mL
Target: Estrogen receptor/ERR; PROTACs
Pathway: Vitamin D related/nuclear receptor; PROTAC

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4,782

Cayman Chemical 1,2-Distearoyl-3-Palmitoyl-rac-glycerol, Purity: ≥95%, CAS: 2177-99-3, 5 mg

A triacylglycerol; has been found in cocoa butter, lard, and cod liver oil

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4,783

Sigma Aldrich Fine Chemicals Biosciences Raloxifene hydrochloride for peak identification European Pharmacopoeia (EP) Reference Standard | 82640-04-8 | MFCD01938233 |

Raloxifene hydrochloride for peak identification European Pharmacopoeia (EP) Reference Standard | Mol Wt: 510.04 | 82640-04-8 | MFCD01938233 |

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4,784

Cayman Chemical Abametapir, Purity: ≥98%, CAS: 1762-34-1, 5 g

A building block and an insecticide; has been used in the synthesis of lanthanide coordination complexes with antifungal activity against C. albicans and divalent vancomycin derivatives with antibacterial activity against vancomycin-resistant enterococci; ovicidal to DDT- and permethrin-resistant head louse eggs (LC50s = 0.108, 0.121, and 0.16% in isopropanol for 0-2-, 3-5-, and 6-8-day-old eggs, respectively)

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4,785

AdipoGen Ursolic acid (500 mg)

Chemical. CAS: 77-52-1. Formula: C30H48O3. MW: 456.711. Ursolic acid is a pentacyclic triterpenoid that has been isolated from M. pumila. Ursolic acid has diverse biological effects, including anti-inflammatory, anticancer, antidiabetic, antiobesity, neuroprotective, cardioprotective, hepatoprotective, antioxidant and antiviral and antibacterial effects. Effects relevant to its anticancer properties include, apoptosis and autophagy induction, preventing angiogenesis, microtubule-destabilizing, induction of cell cycle arrest and inhibition of tumor growth. Ursolic acid inhibits NF-kappa signaling through suppression of IkappaBalpha kinase and p65 phosphorylation. It has been shown to enhance pancreatic beta-cell function in diabetic mice and activates the TGR5 receptor to enhance GLP-1 secretion. Its antiobesity potential is related to inhibiting pancreatic lipase and adipogenesis and increasing insulin sensitivity and inhibiting alpha-glucosidase.

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Medchemexpress LLC (rel)-PROTAC ERRα Degrader-1 | 98.2% | 1 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC (rel)-PROTAC ERRα Degrader-1 | 98.2% | 1 MG